Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients

A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.

Source: Clinical Infectious Diseases - December 15, 2016 Category: Infectious Diseases Authors: Lavergne, R.-A., Chouaki, T., Hagen, F., Toublanc, B., Dupont, H., Jounieaux, V., Meis, J. F., Morio, F., Le Pape, P. Tags: BRIEF REPORTS Source Type: research