Rosuvastatin postconditioning protects isolated hearts against ischemia –reperfusion injury: The role of radical oxygen species, PI3K–Akt–GSK‐3β pathway, and mitochondrial permeability transition pore

ConclusionRosuvastatin prevents myocardial ischemia–reperfusion injury by inducing phosphorylation of PI3K–Akt and GSK‐3β, preventing oxidative stress and subsequent inhibition of mPTP opening.

Source: Cardiovascular Therapeutics - December 12, 2016 Category: Cardiology Authors: Chun ‐Wei Liu, Fan Yang, Shi‐Zhao Cheng, Yue Liu, Liang‐Hui Wan, Hong‐Liang Cong Tags: Original Research Article Source Type: research