Computational resources and tools for antimicrobial peptides

This article reviews the advances of AMP databases and computational tools for the prediction and design of new active AMPs. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. Antimicrobial peptides (AMPs) have been considered to be promising substitutes of conventional antibiotics to combat the challenge of antibiotic resistance. However, most AMPs have modest direct antimicrobial activity, and their mechanisms of action are still poorly understood. This review presents the advances of antimicrobial peptide databases and computational tools for the prediction and design of new active AMPs. The computational strategies provide insight into the activity of AMPs and thus exploit their potential as a new generation of antimicrobials.
Source: Journal of Peptide Science - Category: Biochemistry Authors: Tags: Review Source Type: research