Brain network dysfunction in youth with obsessive-compulsive disorder induced by simple uni-manual behavior: The role of the dorsal anterior cingulate cortex

In an effort to elucidate differences in functioning brain networks between youth with obsessive-compulsive disorder and controls, we used fMRI signals to analyze brain network interactions of the dorsal anterior cingulate cortex (dACC) during visually coordinated motor responses. Subjects made a uni-manual response to briefly presented probes, at periodic (allowing participants to maintain a “motor set”) or random intervals (demanding reactive responses). Network interactions were assessed using psycho-physiological interaction (PPI), a basic model of functional connectivity evaluating modulatory effects of the dACC in the context of each task condition.

Source: Psychiatry Research: Neuroimaging - December 12, 2016 Category: Psychiatry Authors: Amy L. Friedman, Ashley Burgess, Karthik Ramaseshan, Phil Easter, Dalal Khatib, Asadur Chowdury, Paul D. Arnold, Gregory L. Hanna, David R. Rosenberg, Vaibhav A. Diwadkar Source Type: research