Outside the mainstream: novel collecting duct proteins regulating water balance

Body water balance is critical to survival and, therefore, very tightly regulated by the hypothalamus and kidney. A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis. In this Mini-Review, we briefly discuss these novel proteins and their roles in the regulation of water homeostasis.

Source: AJP: Renal Physiology - December 11, 2016 Category: Urology & Nephrology Authors: Rahman, S. S., Boesen, E. I. Tags: MINI-REVIEW Source Type: research