The impact of flutamide on prostaglandin F2 α synthase and prostaglandin F2α receptor expression, and prostaglandin F2α concentration in the porcine corpus luteum of pregnancy

Recently we have indicated that flutamide-induced androgen deficiency diminished progesterone production in the porcine CL during late pregnancy and before parturition, as a sign of functional luteolysis. In pigs, the main luteolytic factor is prostaglandin F2 α (PGF2α), which acts via specific receptors (PTGFRs), and its biosynthesis is catalyzed by prostaglandin F2α synthase (PGFS). The current study investigated the impact of flutamide on luteal PGFS and PTGFR expression, as well as intraluteal PGF2α content during pregnancy in pigs.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research