Development of [11C]/[3H]THK-5351 – A Potential Novel Carbon-11 Tau Imaging PET Radioligand

Due to the rise in the number of patients with dementia the imperative for finding new diagnostic and treatment options becomes ever more pressing. While significant progress has been made in PET imaging of A β aggregates both in vitro and in vivo, options for imaging tau protein aggregates selectively are still limited. Based on the work previously published by researchers from the Tohoku University, Japan, that resulted in the development of [18F]THK-5351, we have undertaken an effort to develop a car bon-11 version of the identical structure - [11C]THK-5351.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research