Suboptimal Adherence to Combination Antiretroviral Therapy Is Associated With Higher Levels of Inflammation Despite HIV Suppression

Conclusions. Higher concentrations of inflammatory biomarkers were observed among HIV RNA–suppressed men who reported <100% cART adherence than among more adherent men. Residual HIV replication (ie, below the limit of detection), more likely among men with suboptimal adherence, is a plausible mechanism. Whether improving cART adherence could affect residual inflammation and associated morbidity and mortality rates should be investigated.

Source: Clinical Infectious Diseases - December 7, 2016 Category: Infectious Diseases Authors: Castillo-Mancilla, J. R., Brown, T. T., Erlandson, K. M., Palella, F. J., Gardner, E. M., Macatangay, B. J. C., Breen, E. C., Jacobson, L. P., Anderson, P. L., Wada, N. I. Tags: HIV/AIDS Source Type: research