Possible role for glomerular-derived angiotensinogen in nephrotic syndrome

Conclusion:
It is conceivable that the promoted local RAS action participated in the glomerular dysfunction, and that ARB treatment ameliorated slit diaphragm injury by inhibiting the positive feedback loop of the activated local Ang II action.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 7, 2016 Category: Biomedical Science Authors: Yamazaki, M., Fukusumi, Y., Kayaba, M., Kitazawa, Y., Takamura, S., Narita, I., Kawachi, H. Tags: Original Article Source Type: research