Anti-mycobacterial function of macrophages is impaired in a diet induced model of type 2 diabetes

In this study, a diet induced murine model of T2D (DIMT2D) was developed and characterized in the context of metabolic, biochemical and histopathological features following diet intervention. Mycobacterial susceptibility was investigated using Mycobacterium fortuitum as a surrogate. Phagocytic capability of alveolar macrophages and resident peritoneal macrophages were determined by in vitro assays using mycolic acid coated beads and M.

Source: Tuberculosis - December 6, 2016 Category: Respiratory Medicine Authors: Md Abdul Alim, Suchandan Sikder, Tahnee L. Bridson, Catherine M. Rush, Brenda L. Govan, Natkunam Ketheesan Source Type: research