Puerarin offsets the anticoagulation effect of Warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin

ConclusionPuerarin increased warfarin metabolism and offset warfarin anticoagulation by inducing rCyps, upregulating VKOR and inhibiting TM in rats. The clinical impact of such potential interactions warrants further verification.

Source: Biopharmaceutics and Drug Disposition - November 30, 2016 Category: Drugs & Pharmacology Authors: Beikang Ge, Zhen Zhang, Teddy Taining Lam, Zhong Zuo Tags: Original Paper Source Type: research