A new molecular paradigm in mycosis fungoides and S ézary syndrome

Mycosis Fungoides (MF) and S ézary Syndrome (SS) are clonal proliferations of mature T-cells manifesting as lymphoproliferative disorders in which the neoplastic cells show a strong propensity for skin-homing. While the predominant site of presentation in MF is the skin, the peripheral blood carries a significant tumor burden in Sézary Syndrome such that it resembles a “leukemic” disease. While the genetic basis of these diseases has been studied using different approaches in the previous years, recent genome-wide studies employing massively parallel sequencing techniques now offer new insights into the molecular pa thogenesis of these diseases.
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research