Results of a Zika Virus (ZIKV) Immunoglobulin M-Specific Diagnostic Assay Are Highly Correlated With Detection of Neutralizing Anti-ZIKV Antibodies in Neonates With Congenital Disease

Conclusions. Among neonates, detection of ZIKV IgM in serum is confirmatory of congenital ZIKV infection, and detection of ZIKV IgM in CSF is confirmatory of neurologic infection. Therefore, we recommend testing for ZIKV IgM in neonates suspected of having congenital ZIKV infection and performance of PRNTs in equivocal cases.

Source: The Journal of Infectious Diseases - December 4, 2016 Category: Infectious Diseases Authors: Cordeiro, M. T., Brito, C. A. A., Pena, L. J., Castanha, P. M. S., Gil, L. H. V. G., Lopes, K. G. S., Dhalia, R., Meneses, J. A., Ishigami, A. C., Mello, L. M., Alencar, L. X. E., Guarines, K. M., Rodrigues, L. C., Marques, E. T. A. Tags: VIRUSES Source Type: research