Phosphoglycerate Kinase--A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation

Conclusions. Taken together, results of this study reveal a novel secreted streptococcal factor that, in the absence of SpeB, can trigger neutrophil activation and degranulation. This finding is of interest in light of reports of hypervirulent SpeB-negative S. pyogenes variants present during invasive infections.

Source: The Journal of Infectious Diseases - December 4, 2016 Category: Infectious Diseases Authors: Uhlmann, J., Siemens, N., Kai-Larsen, Y., Fiedler, T., Bergman, P., Johansson, L., Norrby-Teglund, A. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research