Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria

Conclusions. Simultaneous arginine and ornithine depletion in malaria parasite–infected children cannot be fully explained by plasma arginase activity. Our mouse model studies suggest that plasma arginine depletion is driven primarily by a decreased rate of appearance.

Source: The Journal of Infectious Diseases - December 4, 2016 Category: Infectious Diseases Authors: Alkaitis, M. S., Wang, H., Ikeda, A. K., Rowley, C. A., MacCormick, I. J. C., Chertow, J. H., Billker, O., Suffredini, A. F., Roberts, D. J., Taylor, T. E., Seydel, K. B., Ackerman, H. C. Tags: PARASITES Source Type: research