Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue

Publication date: Available online 2 December 2016 Source:Drug Discovery Today: Technologies Author(s): Thomas Birngruber, Frank Sinner Cerebral open flow microperfusion (cOFM) is a new in-vivo technique for continuous sampling of the interstitial fluid in brain tissue. cOFM can be used to monitor substance transport across the blood–brain barrier (pharmacokinetics) and to investigate metabolic changes in brain tissue after drug application (pharmacodynamics). The possibility of long-term implantation into the brain makes cOFM an outstanding tool in the development of brain relevant pharmaceutics.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research