Synthesis and Organic Impurity Profiling of 4-Methoxymethamphetamine Hydrochloride and its Precursors

4-Methoxymethamphetamine (or p-methoxymethamphetamine, PMMA) is a synthetic substance that is an analogue of methamphetamine and closely related in structure to 3,4-methylenedioxymethamphetamine (MDMA) (Fig. 1) [1]. Drug analogues often appear in the illicit market as substitutes for other substances as well as being marketed in their own right. PMMA is a stimulant with similar [2,3] but possibly more short-lived [4] effects compared to those of MDMA. It has been suggested that there is a small margin between a safe and lethal dose of PMMA [3].
Source: Forensic Science International - Category: Forensic Medicine Authors: Source Type: research