Effects of exendin-4 on the intrarenal renin-angiotensin system and interstitial fibrosis in unilateral ureteral obstruction mice: Exendin-4 and unilateral ureteral obstruction

Conclusion:
Our present study indicates for the first time that exendin-4 exerts renoprotective effects in an experimental model of UUO, partly through regulating the balance of the intrarenal renin-angiotensin system and then inhibiting the Ang II-mediated TGF-β1/Smad3 signaling pathway.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 1, 2016 Category: Biomedical Science Authors: Le, Y., Zheng, Z., Xue, J., Cheng, M., Guan, M., Xue, Y. Tags: Original Article Source Type: research