Molecular cloning, tissue distribution, and pharmacologic characterization of melanocortin-4 receptor in grass carp (Ctenopharyngodon idella)

Melanocortin-4 receptor (MC4R) plays a pivotal role in the mediation of leptin action on food intake and energy expenditure in mammals. The MC4R has also been identified in several teleosts, and its importance in the regulation of fish energy homeostasis is emerging. We herein reported on the molecular cloning, tissue distribution, and pharmacologic characterization of MC4R in grass carp (Ctenopharyngodon idella), an economically and ecologically important fish. We showed that grass carp MC4R (ciMC4R) consisted of a 981  bp open reading frame encoding a protein of 326 amino acids, highly homologous (>95%) to several teleost MC4Rs.

Source: Domestic Animal Endocrinology - November 20, 2016 Category: Endocrinology Authors: L. Li, Z. Yang, Y.-P. Zhang, S. He, X.-F. Liang, Y.-X. Tao Source Type: research