Toxoplasmosis versus Lymphoma: Cerebral Lesion Characterization Using DSC-MRI Revisited

Cerebral toxoplasmosis and lymphoma are the two most common cerebral lesions in patients with acquired immune deficiency syndrome, [1] but both can occur in immune competent patients, and immune status may be unknown at time of imaging. Although imaging-based diagnosis can facilitate early initiation of appropriate therapy, these entities are often indistinguishable by conventional contrast-enhanced MRI. [2,3] Advanced MRI techniques including diffusion-weighted imaging (DWI), MR spectroscopy (MRS), and dynamic susceptibility contrast (DSC) MRI have been used to characterize lymphoma [4 –6] and toxoplasmosis, [7,8] to distinguish lymphoma from other neoplastic processes, [9–12] and to distinguish infectious from neoplastic processes.

Source: Clinical Neurology and Neurosurgery - December 1, 2016 Category: Neurosurgery Authors: Elizabeth H. Dibble, Jerrold L. Boxerman, Grayson L. Baird, John Donahue, Jeffrey M. Rogg Tags: Full Length Article Source Type: research