Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia

In conclusion, 15 mo of DM + HFD, as well as HFD alone, resulted in CMD. Although the overall vasodilation to BK was unperturbed, the relative contributions of NO and endothelium-derived hyperpolarizing factor pathways were altered. Moreover, the vasoconstrictor response to ET-1 was enhanced, involving the ETB receptors. In conjunction with our previous study, these findings highlight the time dependence of the phenotype of CMD.

Source: AJP: Heart and Circulatory Physiology - November 30, 2016 Category: Cardiology Authors: Sorop, O., van den Heuvel, M., van Ditzhuijzen, N. S., de Beer, V. J., Heinonen, I., van Duin, R. W. B., Zhou, Z., Koopmans, S. J., Merkus, D., van der Giessen, W. J., Danser, A. H. J., Duncker, D. J. Tags: CALL FOR PAPERS Source Type: research