Abstract B29: ZNF516 a potential tumor suppressor gene candidate is implied in tumor progression in cervical cancer

Conclusions: There is a clear ZNF516 dysregulation in CC cell lines, and the inactivation mechanism seem to be methylation. Restored expression of ZNF516 in C-33A cell line modifies the tumor phenotype, decreasing cellular viability and colony formation. These results suggest that ZNF516 could be a TSG, and its inactivation promotes CC developing.Citation Format: Carmen Gloria Ili, Tamara Viscarra, Juan Carlos Araya, Jaime Lopez, Barbara Mora, Javier Retamal, Enrique Bellolio, Susana Aedo, Juan Carlos Roa, Priscilla Brebi. ZNF516 a potential tumor suppressor gene candidate is implied in tumor progression in cervical cancer. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(11_Suppl):Abstract nr B29.

Source: Molecular Cancer Research - November 9, 2016 Category: Cancer & Oncology Authors: Ili, C. G., Viscarra, T., Araya, J. C., Lopez, J., Mora, B., Retamal, J., Bellolio, E., Aedo, S., Roa, J. C., Brebi, P. Tags: Other Topics: Poster Presentations - Proffered Abstracts Source Type: research