Serelaxin improves the pathophysiology of placental ischemia in the reduced uterine perfusion pressure rat model of preeclampsia

In conclusion, Serelaxin improved blood pressure, sFlt-1, TNF-α, UARI, and nitric oxide bioavailability and PPET-1 in a rat model of preeclampsia, thereby suggesting a potential therapeutic role for RLX in maintaining maternal health and prolonging pregnancy in the face of placental ischemia.

Source: AJP: Regulatory, Integrative and Comparative Physiology - November 30, 2016 Category: Physiology Authors: Santiago-Font, J. A., Amaral, L. M., Faulkner, J., Ibrahim, T., Vaka, V. R., Cunningham, M. W., LaMarca, B. Tags: Hormones, Reproduction and Development Source Type: research