Testosterone decreases urinary bladder smooth muscle excitability via novel signaling mechanism involving direct activation of the BK channels

In conclusion, the data provide compelling mechanistic evidence that under physiological conditions, testosterone at nanomolar concentrations directly activates BK channels in DSM cells, independent from genomic testosterone receptors, and thus regulates DSM excitability.

Source: AJP: Renal Physiology - November 30, 2016 Category: Urology & Nephrology Authors: Hristov, K. L., Parajuli, S. P., Provence, A., Petkov, G. V. Tags: CALL FOR PAPERS Source Type: research