Genetic, pathophysiological, and clinical aspects of nephrocalcinosis

Nephrocalcinosis describes the ectopic deposition of calcium salts in the kidney parenchyma. Nephrocalcinosis can result from a number of acquired causes but also an even greater number of genetic diseases, predominantly renal but also extrarenal. Here we provide a review of the genetic causes of nephrocalcinosis, along with putative mechanisms, illustrated by human and animal data.

Source: AJP: Renal Physiology - November 30, 2016 Category: Urology & Nephrology Authors: Oliveira, B., Kleta, R., Bockenhauer, D., Walsh, S. B. Tags: REVIEWS Source Type: research