Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane

In conclusion, PP1/PP2A regulates the phosphorylation and apical plasma membrane accumulation of AQP2 differently than PP2B. Serine-264 of AQP2 is a phosphorylation site that is regulated by both PP1/PP2A and PP2B. This dual regulatory pathway may suggest a previously unappreciated role for multiple phosphatases in the regulation of urine concentration.

Source: AJP: Renal Physiology - November 30, 2016 Category: Urology & Nephrology Authors: Ren, H., Yang, B., Ruiz, J. A., Efe, O., Ilori, T. O., Sands, J. M., Klein, J. D. Tags: ARTICLES Source Type: research