Role of O-linked N-acetylglucosamine modification in diabetic nephropathy

In conclusion, hyperglycemia-induced elevation of O-GlcNAcylation contributes to the progression of DN via inhibition of Akt/eNOS phosphorylation and HSP72 induction. RAAS blockers successfully inhibit this process, suggesting a novel pathomechanism of their renoprotective action in the treatment of DN.

Source: AJP: Renal Physiology - November 30, 2016 Category: Urology & Nephrology Authors: Gellai, R., Hodrea, J., Lenart, L., Hosszu, A., Koszegi, S., Balogh, D., Ver, A., Banki, N. F., Fulop, N., Molnar, A., Wagner, L., Vannay, A., Szabo, A. J., Fekete, A. Tags: ARTICLES Source Type: research