In vivo MR imaging of intercellular adhesion molecule‐1 expression in an animal model of multiple sclerosis

In conclusion, ICAM‐1 expression can be visualized with in vivo molecular MRI during EAE, and provides an early tracer of disease activity. Copyright © 2014 John Wiley & Sons, Ltd.
In a model of multiple sclerosis we showed that intracerebral upregulation of intercellular adhesion molecule 1 (ICAM‐1), an early event in lesion formation, was visualized in vivo with MRI using antibody‐labeled micron‐sized particles of iron oxide (MPIO). MPIO presence was not necessarily associated with blood–brain barrier dysfunction. Histochemistry showed that ICAM‐1 was expressed by brain endothelial cells, macrophages and T‐cells, although labeled MPIO were only associated with endothelial cells or cells at the luminal side of blood vessels.

Source: Contrast Media and Molecular Imaging - April 21, 2014 Category: Radiology Authors: Erwin L. A. Blezer, Lisette H. Deddens, Gijs Kooij, Joost Drexhage, Susanne M. A. Pol, Arie Reijerkerk, Rick M. Dijkhuizen, Helga E. Vries Tags: Full Paper Source Type: research