Effect of ABCB1 (3435C & gt;T) and CYP3A5 (6986A & gt;G) genes polymorphism on tacrolimus concentrations and dosage requirements in liver transplant patients

Conclusions ABCB1 and CYP3A5 genetic polymorphism is one of the factors influencing TAC pharmacokinetics, screening for these SNPs prior to liver transplantation might be helpful for individualization of tacrolimus treatment.
Source: Egyptian Journal of Medical Human Genetics - Category: Genetics & Stem Cells Source Type: research