Is There a Genetic Predisposition to Anterior Cruciate Ligament Tear? A Systematic Review

Conclusion: Although specific gene polymorphisms and haplotypes have been identified, it is difficult to come to a conclusion on the basis of the existing literature. Several sources of bias have been identified in these studies, and the results cannot be extrapolated to the general population. More studies are needed in larger populations of different ethnicities. Gene-gene interactions and gene expression studies in the future may delineate the exact role of these gene polymorphisms in ACL tears.
Source: The American Journal of Sports Medicine - Category: Sports Medicine Authors: Tags: Knee ligaments, ACL Current Concepts Source Type: research