Consistent sex-dependent effects of PKM{zeta} gene ablation and pharmacological inhibition on the maintenance of referred pain

Conclusion We show pharmacological inhibition and genetic ablation of PKM consistently attenuate long-lasting pain hypersensitivity. However, differential effects in models of referred versus inflammatory and neuropathic pain, and in males versus females, highlight the roles of afferent input-dependent masking and sex differences in the maintenance of pain hypersensitivity.

http://mpx.sagepub.com/cgi/content/abstract/12/0/1744806916675347?rss=1

Source: Molecular Pain - November 28, 2016 Category: Molecular Biology Authors: Nasir, H., Mahboubi, H., Gyawali, S., Ding, S., Mickeviciute, A., Ragavendran, J. V., Laferriere, A., Stochaj, U., Coderre, T. J. Tags: Research Article Source Type: research