Common variation of the CYP17gene in Iraqi women with endometriosis disease

Publication date: Available online 29 November 2016 Source:Genomics Data Author(s): Salwa Hameed Naser, Tamara S Naji, Kismat M Turki Common variants among genes coding for enzymesin sex steroid biosynthetic pathways may influence the riskof endometriosis in Iraqi women patients in the last years. Cytochrome P450c17a1 (CYP17), a gene that codesfor a key enzyme (cytochrome P450c17a1) in a rate-limitingstep of estrogen biosynthesis has attracted considerableattention as an important gene for endometriosis.To evaluate the relationship between common genetic variations in CYP17 and endometriosis riskand determine the main effects of those variations on the gene expression.Awomen-based case control study of Iraqi women aged range (23–46), the associations betweenselected single-nucleotide polymorphisms (SNPs) in the CYP17 gene and endometriosis diagnosis in fiftywomen andthirty disease-free controls was evaluated.The study found a significant association(P ≤0.01)between endometriosis and selected SNPs of CYP17 gene, with the homozygous genotype conferring decreased risk. A highly significant difference (P ≤0.01) in CYP17gene expression from women with versus without endometriosis and increased by 1.56-fold in women with endometriosis. These findings suggest that variation in or around CYP17may be associated with endometriosis development in the Iraqi women.
Source: Genomics Data - Category: Genetics & Stem Cells Source Type: research