Active efflux in dormant bacterial cells – new insights into antibiotic persistence
Bacterial persisters are phenotypic variants of an isogenic cell population that can survive antibiotic treatment and resume growth after the antibiotics have been removed. Cell dormancy has long been considered the principle mechanism underlying persister formation. However, dormancy alone is insufficient to explain the full range of bacterial persistence. Our recent work revealed that in addition to ‘passive defense’ via dormancy, persister cells employ ‘active defense’ via enhanced efflux activity to expel drugs.
Source: Drug Resistance Updates - Category: Drugs & Pharmacology Authors: Yingying Pu, Yuehua Ke, Fan Bai Source Type: research
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