Novel insights on understanding of Keloid Scar: Article Review

Keloid scar, dermal benign fibro proliferative growth that extend outside the original wound and invade adjacent dermal tissue due to extensive production of extracellular matrix, especially collagen, which caused by over expression of cytokines and growth factors. Although many attempt were made to understand the exact pathophysiology and the molecular abnormalities, the pathogenesis of keloid scar is yet to be determined. Even though there are several treatment options for keloid scars includes combination of medical and surgical therapies like combination of surgical removal followed by cryotherapy or intralesional steroid therapy, the reoccurrence rate is still high despite the present treatment.
Source: Journal of the American College of Certified Wound Specialists - Category: Dermatology Authors: Source Type: research