Cortical-Amygdala Volumetric Ratios Predict Onset of Symptoms of Psychosis in 22q11.2 Deletion Syndrome

Dysfunction of cortical circuitry involving prefrontal cortex, cingulate gyrus and mesial temporal lobe has been implicated in the pathophysiology of psychotic symptoms. 22q11.2 deletion syndrome (22q11DS) is a neurogenetic disorder that comports a 25-fold increased risk of developing psychosis. Morphological changes in the neuroanatomy of this syndrome may represent a biological risk factor for the development of psychosis. The present study explored ratios between cortical volumes and the amygdala.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research