Animal models of local aortic stiffening: The effect of salt in SHRSP

Objectives: The cardiovascular risk associated with central artery stiffening is recognized but better understanding of the mechanisms and therapeutic strategies are needed. Therefore, animal models for evaluating stiffness are crucial. We and others use different approaches to calculate aortic stiffness. Pulse wave velocity (PWV) is relatively easily measured and is indispensable, despite being highly influenced by blood pressure. Local determination using echotracking allows us to determine stiffness at various levels of the arterial tree and to measure the pulsatile diameter wave (distension).
Source: Artery Research - Category: Cardiology Authors: Source Type: research