TNF- antagonists improve arterial stiffness in patients with rheumatoid arthritis: a meta-analysis

Purpose/Background/Objectives: Patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and an increased inflammatory burden that might be associated with their increased cardiovascular risk. Tumor necrosis factor alpha (TNF)-antagonists have been found to reduce inflammatory markers in RA however it is debatable if they have favorable effects on surrogate markers of cardiovascular outcomes. We conducted a meta-analysis to assess the effect of TNF-antagonists on arterial stiffness, a predictor of cardiovascular events and mortality, in RA patients.
Source: Artery Research - Category: Cardiology Authors: Source Type: research