Arterial phenotype modulation and regulation of vascular fibrosis in mice by conditional inactivation of integrin av subunit in vascular smooth muscle cells

Integrin αv functions as a receptor for adhesion proteins and is expressed at high density in vascular smooth muscle cells (VSMC)1,2,3,4,5 whose phenotypic modulation plays a crucial role in arterial ageing and atherosclerosis.6,7.

Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Ekaterina Belozertseva, Huguette Louis, Zhenlin Li, Mustapha Bourhim, Dominique Dumas, Veronique Regnault, Patrick Lacolley Source Type: research