An associated with Familial Hemiplegic Migraine Type 2 mutation in the alpha-2 isoform Na,K-ATPase disturbs vascular responses in mouse brain

Objectives: Migraine attack is associated with severe changes in brain perfusion vasoconstriction-induced hypoxemia during aura and rebound vasodilation in subsequent headache. Familial Hemiplegic Migraine Type 2 is associated with point mutations (including G301R) in the α2 isoform Na,K-ATPase. Heterozygote mice bearing G301R mutation (FHM2) were recently characterized for several behavioral and neuronal abnormalities.

Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Christian Staehr, Lise Hangaard, Karin Lykke-Hartmann, Elena Bouzinova, Christian Aalkjaer, Vladimir Matchkov Source Type: research