Age-dependent telomere attrition, short telomeres and atherosclerosis

Background: Short leukocyte telomere length (LTL) is associated with atherosclerosis. The prevailing view is this association exists since LTL is a biomarker of cumulative inflammation and oxidative stress during adult life. However recent studies show that LTL in adults is defined mainly by LTL at birth and attrition during childhood. Therefore we can suggest that short LTL might precede clinical expression of atherosclerosis.

Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Simon Toupance, Anna Kearney-Schwartz, Mohamed Temmar, C écile Lakomy, Carlos Labat, Patrick Rossignol, Faiez Zannad, Patrick Lacolley, Abraham Aviv, Athanase Benetos Source Type: research