Deletion of chromosome 9P21 noncoding cardiovascular risk interval in mice induces a prothrombotic phenotype

Background: SNPs on chromosome 9p21.3 risk locus have been associated with cardiovascular diseases. We have established a direct mechanistic link between 9p21 noncoding risk interval and susceptibility to aneurysm in a mouse model with a targeted deletion of the 9p21 noncoding cardiovascular disease risk interval.

Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Amel Mohamadi, Mustapha Bourhim, Gemma Basatemur, Huguette Louis, Athanase Benetos, Patrick Lacolley, Ziad Mallat, Veronique Regnault Source Type: research