Prevention of neural tube defects in Lrp mutant mouse embryos by folic acid supplementation

ConclusionLrp2 is required for folate homeostasis in heterozygous dams and high levels of supplementation prevents NTDs. Furthermore, high levels of dietary iron supplementation interfered with folic acid supplementation negating the positive effects of supplementation in this model. Birth Defects Research (Part A), 2016. © 2016 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 30, 2016 Category: Perinatology & Neonatology Authors: Julia A. Sabatino, Bethany A. Stokes, Irene E. Zohn Tags: Original Research Article Source Type: research