Analysis of the functional muscle –bone unit of the forearm in patients with phenylketonuria by peripheral quantitative computed tomography

In conclusion, the radial bone in PKU patients is characterized by reduced bone strength in relation to muscular force, decreased cortical thickness, and impaired total BMD at the metaphyseal site. These alterations indicate a mixed bone defect in PKU, both of which are due to primary alterations of bone metabolism and to secondary alterations in response to neuromuscular abnormalities.
Source: Journal of Inherited Metabolic Disease - Category: Internal Medicine Source Type: research