Human gingival fibroblasts induced and differentiated into vascular endothelial ‐like cells

In conclusion, we found that HGFs possessed capacity for being induced and differentiated into vessel endothelial‐like cells with typical and specific morphological, ultrastructural, and immunological characters of endothelial‐like cells by induction with VEGF. Human gingival fibroblast was found with the characteristic of stem cell, and it was able to induce differentiation into vascular endothelial cell. The optimal condition of induced differentiation was also determined: the differentiation could be induced in serum‐free Dulbecco's modified eagle medium for 35 days with the VEGF165 treatment concentration of 8 ng/mL. The induced cells possessed the characteristic of endothelial cells, such as morphology, immunologic, and formation of tube‐like structure.
Source: Development, Growth and Differentiation - Category: Research Authors: Tags: Original Article Source Type: research