Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis

In conclusion, this mouse model supports the role of prkar1a as a tumor suppressor gene in the pancreas and points to the PKA pathway as a possible therapeutic target for these lesions.

Source: Endocrine-Related Cancer - November 22, 2016 Category: Endocrinology Authors: Saloustros, E., Salpea, P., Starost, M., Liu, S., Faucz, F. R., London, E., Szarek, E., Song, W.-J., Hussain, M., Stratakis, C. A. Tags: Research Source Type: research