Oleuropein Aglycone Enhances UCP1 Expression in Brown Adipose Tissue in High-Fat-Diet-Induced Obese Rats by Activating β-Adrenergic Signalling

Oleuropein is the pungent principle of raw olives. Oleuropein aglycone (OA) is a major phenolic compound in extra virgin olive oil and the absorbed form of oleuropein.We aimed to determine the mechanism underlying the nutritional effects of oleuropein and OA on interscapular brown adipose tissue (IBAT) in rats with high-fat (HF) diet-induced obesity by examining the agonistic activity of oleuropein and OA toward the transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1).Four-week-old-male Sprague –Dawley rats were fed a HF (palm oil 30% wt:wt) diet alone or with oleuropein (HF-O, 1 g/kg diet) for 28 d.

Source: The Journal of Nutritional Biochemistry - November 22, 2016 Category: Biochemistry Authors: Yuriko Oi-Kano, Yusaku Iwasaki, Toshiyuki Nakamura, Tatsuo Watanabe, Tsuyoshi Goto, Teruo Kawada, Kenichi Watanabe, Kazuo Iwai Source Type: research