Rejuvenation of aged hematopoietic stem cells

Until recently, there was broad consensus in the stem cell aging field that the phenotype of aged hematopoietic stem cells (HSCs) is fixed —dominated by cell-intrinsic regulatory mechanisms that cannot be altered by pharmacological or genetic means. The conventional thinking was that HSC aging could not be reverted by therapeutic intervention. This paradigm has started to shift dramatically, primarily because hallmarks of aged HSCs h ave been successfully reverted by distinct experimental approaches by multiple laboratories.
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research