A Prospective Natural History Study of  Coronary Atherosclerosis Using Fractional Flow Reserve

This study sought to investigate the relationship between FFR values and vessel-related clinical outcome.MethodsWe prospectively studied major adverse cardiovascular events (MACE) at 2 years in 607 patients in whom all stenoses were assessed by FFR and who were treated with medical therapy alone. The relationship between FFR and 2-year MACE was assessed as a continuous function. Logistic and Cox proportional hazards regression models were used to calculate the average decrease in the risk of MACE per 0.05-U increase in FFR.ResultsMACE occurred in 272 (26.5%) of 1,029 lesions. Target lesions with diameter stenosis  ≥70% were more often present in the MACE group (p 
Source: Journal of the American College of Cardiology - Category: Cardiology Source Type: research