Accumulation of DNA damage in the aged hematopoietic stem cell compartment

Aging is associated with loss of functional potential of multiple tissue systems, and there has been significant interest in understanding how tissue specific cells contribute to this decline. DNA damage accumulation has been widely associated with aging in differentiated cell types. However, tissue specific stem cells were once thought to be a geno-protected population, as damage accrued in a stem cell population has the potential to be inherited by differentiated progeny as well as propagated within the stem cell compartment through self-renewal divisions.
Source: Seminars in Hematology - Category: Hematology Authors: Tags: 54/1 Aging and Hematopoiesis Source Type: research