Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate ‐induced neural tube closure defects

ConclusionMaternal VPA treatment markedly perturbed purine and pyrimidine metabolism in E9.5 embryos. In combination with a high FA diet, VPA treatment resulted in gross metabolic changes, likely caused by a multiplicity of mechanisms, including an apparent disruption of mitochondrial beta‐oxidation. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fbdra.23583

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 30, 2016 Category: Perinatology & Neonatology Authors: Darya Akimova, Bogdan J. Wlodarczyk, Ying Lin, M. Elizabeth Ross, Richard H. Finnell, Qiuying Chen, Steven S. Gross Tags: Original Research Article Source Type: research